By Drew Provan
This moment version of the ABC of scientific Haematology is a finished and useful consultant to this huge ranging speciality, overlaying the haematological facets of such parts as pathology, molecular technology, melanoma, and common medication. this can be a brief quantity along with chapters on all parts of haematology written by means of those that take care of those ailments each day. The publication presents descriptions of those ailments and describes the pathways desirous about analysis and therapy. complete color is used all through this seriously illustrated ebook, utilizing scientific fabric and textual content bins to emphasize key issues. we've got additionally attempted to maintain jargon to a minimal in order that the textual content doesn't require vast past wisdom.
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Additional resources for ABC of Clinical Haematology (ABC Series)
Much rarer features at presentation include non-specific fever, lymphadenopathy, visual disturbances due to leucostasis (a form of hyperviscosity caused by an extremely high white cell count) or retinal haemorrhages, splenic pain due to infarction, gout and occasionally priapism. The commonest physical sign at diagnosis is an enlarged spleen (Fig. 3 Patient with massive splenomegaly in chronic phase chronic myeloid leukaemia. towards the right iliac fossa. The liver may be enlarged, with a soft, rather ill-defined lower edge.
Infiltration Leukaemic blasts can infiltrate any organ. Bone pain is a direct consequence of marrow disease. Infiltration of the meninges, resulting in headache or cranial nerve palsies, is particularly common in ALL and consequently lumbar puncture is mandatory in newly diagnosed patients with ALL. Hepatosplenomegaly is frequently present at diagnosis in ALL, and mediastinal enlargement is well documented in T-cell ALL. ALL can also involve the testes, presenting with a painful testicular mass.
Even if the neutrophil count appears normal, neutrophil function can often be poor, particularly in patients with a prior history of myelodysplastic syndrome in which neutrophils are usually dysfunctional. Bleeding Bleeding can occur as a consequence of thrombocytopenia or abnormal coagulation. Spontaneous bruising, gingival bleeding, palatal and retinal haemorrhages, epistaxis, menorrhagia and prolonged bleeding after venepuncture are all relatively common. Infiltration Leukaemic blasts can infiltrate any organ.