By F. Melchers (auth.), Dominique Dunon Ph.D., Charles R. Mackay Ph.D., Beat A. Imhof Ph.D. (eds.)
This quantity of present issues in Microbiology and Immunology used to be deliberate in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held on the Basel Institute for Immunology in November 1992, and plenty of of the workshop audio system have contributed to it. phone adhesion is among the such a lot dynamic fields of organic learn and awarded during this booklet is the present wisdom at the constitution and serve as of the most important households of cellphone adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. advanced interactions among the participants of those households mediate diversified adhesion capabilities, together with leukocyte-leukocyte interactions, lymphocyte homing, irritation, and lymphocyte-stromal telephone interplay in the course of hematopoiesis. loads of emphasis is put on the regulatory components that keep watch over the expression and serve as of adhesion molecules. Cytokines not just result in the expression of sure adhesion molecules, yet can also regulate their practical prestige. for example, the integrins exist in both an inactive nonfunctional shape or an lively sensible shape, and a couple of intracellular or extracellular stimuli adjust integrin functionality. this is often rather very important in the course of leukocyte binding to endothelium and transendothelial migration, which proceeds via a cascade of adhesion occasions. even though cellphone adhesion molecules play a tremendous function in lots of procedures, this publication concentrates on their function in the immune method. a couple of chapters speak about the migration of lymphocytes among hematopoietic organs comparable to the thymus, lymph nodes, Peyer's patches, and spleen.
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Additional resources for Adhesion in Leukocyte Homing and Differentiation
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