Advances in Surgical Pathology: Mesothelioma by Richard L. Attanoos

By Richard L. Attanoos

Advances in Surgical Pathology: Mesothelioma, a quantity within the Advances in Surgical Pathology sequence, good points chapters on present and forthcoming alterations within the box with an emphasis on sensible concerns, fresh advancements, and rising concepts.

 Created as a brief overview, this quantity promises a concise, up-to-date overview of the pathological features of mesothelioma—emphasizing the histologic correlation, scientific administration, and remedy of the disease.  well timed content material gains comprise attractiveness of precursor mesothelial lesions, the function of molecular biology within the prognosis and diagnosis of mesothelioma, the interface among the clinician and the surgical pathologist, and the criminal implications of attributing affliction starting place to asbestos and different elements. The publication offers a source for the periodic updates in wisdom required for day-by-day perform, for present credentialing, and for the self-assessment modules for recertification. 

  • Concise and useful format presents a short overview of mesothelioma perfect for citizens, fellows, practising pathologists, and clinicians. 
  • Core content material addresses mesothelioma prognosis, WHO class, staging, imaging, biopsy, mimicking stipulations, immunohistochemistry, distinctive gene remedy, and the possibility of stem phone treatment.
  • Focus on contemporary advances and rising technologies is helping consultant readers’ medical care whilst treating sufferers with mesothelioma.
  • Over a hundred and ten full-color images increase diagnostic accuracy.

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21 Patients underwent both FDG-PET and conventional radiologic response assessment before and after one cycle of chemotherapy. Quantitative volume-based FDG-PET analysis was performed to obtain the total glycolytic volume (TGV) of the tumor. Of 23 patients suitable for both radiologic and FDG-PET analysis, 20 had CT measurable disease. After one cycle of chemotherapy, 7 patients attained a partial response and 13 had stable disease on CT by modified RECIST criteria. In the 7 patients with radiologic partial response, the median TGV on quantitative PET analysis fell to 30% of baseline (range, 11% to 71%).

14 Forty-nine patients with p ­ otentially resectable disease on CT scan underwent contrast-enhanced MRI. 13,14 Entwisle et al. propose that contrast-enhanced MRI is more accurate than unenhanced MRI when used for predicting resectability. 15 If there is any doubt about the potential resectability of disease, then MRI should be considered to avoid the morbidity of unnecessary thoracotomy. Positron Emission Tomography–Computed Tomography The rapid evolution of technology has meant that positron emission tomography–computed tomography (PET–CT) is becoming more widely available and is being used for the investigation of malignant pleural mesothelioma (MPM) despite relatively limited data to support its use.

Renshaw AA, Dean BR, Antman KH, et al. The role of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma. Chest 1997;111:106–109. (c) 2015 Wolters Kluwer. All Rights Reserved. Chapter 4 • Imaging 31 5. Adams RF, Gray W, Davies RJ, et al. Percutaneous image-guided cutting needle biopsy of the pleura in the diagnosis of malignant mesothelioma. Chest 2001;120:1798–1802. 6. Maskell NA, Gleeson FV, Davies RJ. Standard pleural biopsy versus CT-guided cutting-needle biopsy for diagnosis of malignant disease in pleural effusions: a randomised controlled trial.

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